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p63, a p53 homologue, compensates for functional p53 in the oral-esophageal epithelium in p53 deficient mice

✍ Scribed by Avandhani, Anjali; Suliman, Yasir; Opitz, Oliver; Williams, Noel; Burnes, Tim; El-Deiry, Wafiq; Rustgi, Anil X.

Book ID
124115096
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
178 KB
Volume
120
Category
Article
ISSN
0016-5085

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Mice lacking both p18 Ink4c and p27 Kip1 develop a tumor spectrum similar to pRb ΓΎ/Γ€ mice, and loss of p53 function accelerates tumorigenesis in pRb ΓΎ/Γ€ mice. We hypothesized that codeletion of either p18 or p27 in conjunction with p53 deletion will also accelerate tumorigenesis. Mice lacking both p