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P63, a p53 homologue, compensates for functional p53 in the oral-esophageal epithelium of p53 deficient mice

✍ Scribed by Yasir Suliman; Oliver G. Opitz; Anil K. Rustgi


Book ID
119425396
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
378 KB
Volume
118
Category
Article
ISSN
0016-5085

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p63 and p73 are functionally and structurally related to the tumor suppressor p53. However, their own role in tumor suppression is unclear. Given the p53-like properties of p63 and p73, we tested whether they are involved in tumor suppression by aging mice heterozygous for mutations in all p53 famil