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p53 triggers apoptosis in oncogene-expressing fibroblasts by the induction of Noxa and mitochondrial Bax translocation

✍ Scribed by Schuler, M; Maurer, U; Goldstein, J C; Breitenbücher, F; Hoffarth, S; Waterhouse, N J; Green, D R


Book ID
110016510
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
319 KB
Volume
10
Category
Article
ISSN
1350-9047

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Codon 273 is one of the hot spots of missense mutation of the p53 tumor suppressor gene found in human cancers. We have previously reported that a mutation at codon 273, p53-273L (Arg 3 Leu), suppresses cell growth despite its having no p53-specific transactivation activity. To further elucidate the