p53 sends nucleotides to repair DNA
β Scribed by Lozano, Guillermina; Elledge, Stephen J.
- Book ID
- 109767853
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 110 KB
- Volume
- 404
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/35003670
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With ulcerative colitis (UC)-associated tumorigenesis, p53 gene alteration is considered to be a key event. To clarify whether the p53-checkpoint is operating in foci of inflammation and that its disruption is a feature of UC-associated neoplasms, the present immunohistochemical study was conducted.
The number and diversity of mutations in the p53 muta-smoke component benzo [a]pyrene representing the tion data base provides indirect evidence that impli-polycyclic aromatic hydrocarbon class of carcinogens. cates environmental mutagens in human carcinogene-The damage/repair data obtained for thes