BRCA1 was the first breast cancer susceptibility gene to be identified and cloned. In individuals from high-risk families, mutations in BRCA1 increase the lifetime risk of developing breast cancer eight to tenfold, compared to the general population. How the BRCA1 protein product normally functions
BRCA1 and p53: compensatory roles in DNA repair
β Scribed by Anne-Renee Hartman; JamesM. Ford
- Book ID
- 105796120
- Publisher
- Springer
- Year
- 2003
- Tongue
- English
- Weight
- 225 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0946-2716
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Breast cancer is one of the most common malignancies among women. The molecular mechanisms involved in breast carcinogenesis, however, remain to be elucidated. Although somatic mutation of BRCA1 is rare, BRCA1 protein expression is reduced in about 30% of sporadic breast carcinomas (Yoshikawa et al.
## Abstract Mutations of BRCA1 gene are associated with more than half the cases of hereditary breast cancer. Breast cancer formation in BRCA1 mutation carriers is generally accompanied by loss of the wildβtype allele, suggesting that BRCA1 protein may function as a tumor suppressor. The human BRCA
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