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p53 protein expression in patients with hepatocellular carcinoma from the high incidence area of Guangxi, Southern China

✍ Scribed by Guozhong Qin; Jianjia Su; Yaoyu Ning; Xiaoxian Duan; Dan Luo; Prabhakar D Lotlikar

Book ID
117468646
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
181 KB
Volume
121
Category
Article
ISSN
0304-3835

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## Abstract Hepatocellular carcinoma (HCC) is frequent in areas of high exposure to aflatoxin and high prevalence of HBV infection, such as western Africa and south‐east China. A selective mutation in __TP53__ (AGGβ†’AGT at codon 249, Argβ†’Ser) has been identified as a hotspot in HCCs from such areas,

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## BACKGROUND. Multifocal occurrence of precancerous and cancerous lesions of the esophagus has been observed among individuals in a high incidence area for esophageal carcinoma in Henan Province, China. Results from recent studies suggest that p53 protein accumulation and mutation occur early in