p53 protein accumulation and gene mutations in multifocal esophageal precancerous lesions from symptom free subjects in a high incidence area for esophageal carcinoma in Henan, China
✍ Scribed by Li Dong Wang; Qi Zhou; Jun-Yan Hong; Song-Liang Qiu; Chung S. Yang
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 624 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
✦ Synopsis
BACKGROUND.
Multifocal occurrence of precancerous and cancerous lesions of the esophagus has been observed among individuals in a high incidence area for esophageal carcinoma in Henan Province, China. Results from recent studies suggest that p53 protein accumulation and mutation occur early in the pathogenesis of esophageal carcinoma. Discordant p53 gene mutations have been observed in invasive carcinoma and preinvasive lesions from a patient with esophageal carcinoma. The p53 alterations in multifocal precancerous lesions from symptomfree subjects, however, have not been investigated.
METHOD.
Two biopsy samples, one each from the middle-third and the lower-third of the esophagus, from each subject, were taken from 55 symptom-free subjects in a high incidence area for esophageal cancer in Huixian, Henan Province, China. p53 protein accumulation and p53 gene mutation were analyzed in multifocal esophageal precancerous lesions from these subjects.