Background The oncogene product EGF-receptor (EGF-R), the tumor suppressor gene product p53, and anti-p53 antibodies are detectable in serum of certain cancer patients. Increased levels of some of these products were reported in lung cancer patients after occupational asbestos exposure, after exposu
p53 protein, EGF receptor, and anti-p53 antibodies in serum from patients with occupationally derived lung cancer
β Scribed by Schneider, J; Presek, P; Braun, A; Bauer, P; Konietzko, N; Wiesner, B; Woitowitz, H-J
- Book ID
- 110002419
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 103 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0007-0920
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p53 tumour suppressor gene alterations are one of the most frequent genetic events in lung cancer. A subset of patients with p53 mutation and cancer exhibited circulating serum anti-p53 self-antibodies (p53-Ab). The prevalence of these antibodies in lung cancer is currently being analysed in a multi
## Abstract Antibodies reacting with the host protein p53 were found in the sera of patients with primary or secondary carcinoma of the breast. Fourteen out of the 155 sera from breast cancer patients tested were positive for antiβp53 antibodies (9%) and no positives were detected among 164 control