p53 point mutations in primary human gastric carcinomas
✍ Scribed by Hiroshi Yokozaki; Hiroki Kuniyasu; Yasuhiko Kitadai; Kenji Nishimura; Hiroko Todo; Ayşe Ayhan; Wataru Yasui; Hisao Ito; Eiichi Tahara
- Book ID
- 112498089
- Publisher
- Springer-Verlag
- Year
- 1992
- Tongue
- English
- Weight
- 536 KB
- Volume
- 119
- Category
- Article
- ISSN
- 1432-1335
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## Abstract Human Chk1 and Chk2 are DNA damage–activated protein kinases that function as downstream mediators of ataxia‐telangiectasia mutated (ATM), which is involved in G~2~/M cell cycle arrest. To clarify the relation between the expression of Chk1/Chk2 and __p53__ gene status in human gastric
Mutations in the p53 gene are associated with a wide variety of human malignancies. Point mutation in one allele and loss of the remaining one generally lead to inactivation of p53 protein. A high frequency of allelic losses corresponding to the I7p 13.3 region that contained the p53 gene sequence