In this study, we analyzed 53 oral squamous-cell carcinomas among Indians for the presence of alterations in the tumorsuppressor gene p53 by PCR-SSCP and sequencing methods. Our results showed that 21% (I 1/53) of oral carcinomas analyzed carried mutations within the exons 5-8 of the p53 gene. We h
P53 Gene Mutations in Pituitary Carcinomas
โ Scribed by Yoshinori Tanizaki; Long Jin; Bernd W. Scheithauer; Kalman Kovacs; Federico Roncaroli; Ricard V. Lloyd
- Book ID
- 107571781
- Publisher
- Springer US
- Year
- 2007
- Tongue
- English
- Weight
- 181 KB
- Volume
- 18
- Category
- Article
- ISSN
- 1046-3976
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Mutations in the p53 gene are associated with a wide variety of human malignancies. Point mutation in one allele and loss of the remaining one generally lead to inactivation of p53 protein. A high frequency of allelic losses corresponding to the I7p 13.3 region that contained the p53 gene sequence
## Abstract Although carcinoma of the uterine endometrium is the most frequently diagnosed malignancy of the female reproductive tract, the molecular genetic features of this tumor have yet to be described in significant detail. Since mutations of the __p53__ tumor suppressor gene are the single mo