p53 mutations in lung cancers from non-smoking atomic-bomb survivors
โ Scribed by Y Takeshima; WP Bennett; CE Land; CC Harris; Y Takeshima; K Inai; Y. Takeshima; T Seyama; M Akiyama; S Tokuoka; K Mabuchi
- Book ID
- 118553260
- Publisher
- The Lancet
- Year
- 1993
- Tongue
- English
- Weight
- 245 KB
- Volume
- 342
- Category
- Article
- ISSN
- 0140-6736
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๐ SIMILAR VOLUMES
Validated markers are needed to identify operable lung cancer patients with poor prognosis. About one-half of nonsmall-cell lung cancers (NSCLCs) carry a mutation in the p53 tumor-suppressor gene. We examined 101 NSCLC patients for surgical stage, completeness of resection, tobacco smoking, asbestos
## Abstract Our previous study showed a characteristic p53 mutational spectrum in lung tumors from lung cancer patients in the Western Pennsylvania region. To further understand the involvement of p53 mutations in lung tumor development, in this study we compared p53 mutational spectra and distribu