P53 mutations in head and neck carcinoma: correlating current detection methods
β Scribed by Thomas R. Lowry; Joseph A. Brennan
- Book ID
- 117399531
- Publisher
- SAGE Publications
- Year
- 2003
- Tongue
- English
- Weight
- 34 KB
- Volume
- 129
- Category
- Article
- ISSN
- 0194-5998
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## Background: A critical factor for successful organ preservation treatment in head and neck cancer may be selecting tumors that respond to chemotherapy and radiation. previous results in patients indicated that tumors that overexpressed p53 were more sensitive to chemotherapy than those that did
## Background: Mutations of the p53 tumor-suppressor gene are common in squamous cell carcinoma of the head and neck (scchn) and may portend a worse prognosis. human papillomavirus (hpv) represents another potential prognostic factor for scchn. the oncogenic potential of hpv may be due to the abili