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p53 mutations in esophageal tumors from high-incidence areas of China

✍ Scribed by Yuan-Yuan Liang; Asuncion Estève; Ghyslaine Martel-Planche; Satoru Takahashi; Shih-Hsin Lu; Ruggero Montesano; Monica Hollstein

Publisher
John Wiley and Sons
Year
1995
Tongue
French
Weight
636 KB
Volume
61
Category
Article
ISSN
0020-7136

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✦ Synopsis

Carcinomas

of the upper digestive tract (squamous-cell carcinoma of the esophagus, adenocarcinoma of the cardia) from 24 patients residing in Linxian (China) and near-by high-incidence areas were analyzed for mutations in exons 5-8 of the p53 tumor-suppressor gene. Mutations were identified by polymerase chain reaction amplification and direct sequencing in 50% of the specimens. Eleven tumors harbored a single base-pair substitution leading to either an amino-acid substitution (8 tumors) or a chain-termination signal (3 tumors), and one tumor revealed a 15-bp deletion in exon 7 with a silent base substitution adjacent to the deletion site. Mutations occurred in all 4 exons examined, with a preponderance in exon 5. Of the 6 mutations identified among the I 4 adenocarcinomas examined, 3 were G to T transversions, a mutation that has thus far been absent from reported mutations in Barrett's esophageal adenocarcinomas and dysplasias from patients residing in Europe and North America.

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