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P53 Mutations as a possible predictor of response to chemotherapy in metastatic colorectal cancers

✍ Scribed by J. Benhattar; J.P. Cerottini; E. Saraga; G. Metthez; J.C. Givel

Book ID
114136477
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
79 KB
Volume
91
Category
Article
ISSN
0165-4608

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Although intrahepatic infusion therapy with 5-fluorouracil for unresectable colorectal liver metastases may lead to improved overall survival for some patients, it is not clear why a response is not observed in others. Gene alterations in oncogenes or tumor-suppressor genes are critical events in tu