✦ LIBER ✦
p53 mutations as a possible predictor of response to chemotherapy in metastatic colorectal carcinomas
✍ Scribed by Jean Benhattar; Jean-Philippe Cerottini; Emilia Saraga; Geneviève Metthez; Jean-Claude Givel
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- French
- Weight
- 310 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
✦ Synopsis
Although intrahepatic infusion therapy with 5-fluorouracil for unresectable colorectal liver metastases may lead to improved overall survival for some patients, it is not clear why a response is not observed in others. Gene alterations in oncogenes or tumor-suppressor genes are critical events in tumor formation, and some of them could play a role in the process of drug resistance. The tumor-suppressor gene p53, which is known to