𝔖 Bobbio Scriptorium
✦   LIBER   ✦

p53 mutation and absence of mdm2 amplification and Ki-ras mutation in 4-hydroxyamino quinoline 1-oxide induced transplantable osteosarcomas in rats

✍ Scribed by Akira Kido; Toshifumi Tsujiuchi; Masahiro Tsutsumi; Makoto Takahama; Eijiro Okajima; Kunihiko Kobitsu; Yoshizumi Miyauchi; Yoshio Mii; Susumu Tamai; Yoichi Konishi


Book ID
117468400
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
639 KB
Volume
112
Category
Article
ISSN
0304-3835

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Infrequent Ha-ras mutations and absence
✍ Masumi Suzui; Naoki Yoshimi; Takuji Tanaka; Hideki Mori 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 582 KB

## Abstract The alkylating agent 4‐nitroquinoline 1‐oxide (4‐NQO) is a powerful carcinogen and induces squamous cell hyperplasia, squamous cell dysplasia, papilloma, and squamous cell carcinoma (a) in rat oral epithelia. Oral cancers induced by a single application of 4‐NQO develop through a multis

Absence of p53 mutations and various fre
✍ Yoshihiko Tokusashi; Ikue Fukuda; Katsuhiro Ogawa 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 638 KB

## Abstract Mutations of __p53__ and Ki‐__ras__ exon 1 were investigated in rat hepatic lesions induced by four kinds of hepatocarcinogenic protocols: continuous feeding of 3′‐methyl‐4‐dimethylaminoazobenzene (3′‐Me‐DAB), daily intraperitoneal injection of aflatoxin B, (AFB,), and the Soft and Farb

Frequent mutations of Ki-ras but no muta
✍ Hiromichi Kitada; Masahiro Tsutsumi; Toshifumi Tsujiuchi; Makoto Takahama; Tomok 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 591 KB

Point mutations of the Ki-ras andp53 genes in rat lung lesions induced by N-nitrosobis(2-hydroxypropy1)amine (BHP) were investigated by polymerase chain reaction-single-strand conformation polymorphism analysis followed by direct sequencing using paraffin-embedded tissues. Male Wistar rats 6 wk old

Rare mutations of p53, Ki-ras, and β-cat
✍ Yoshikazu Hirayama; Kuniko Wakazono; Masami Yamamoto; Motoo Kitano; Masae Tatema 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 186 KB 👁 1 views

Rat stomach cancers induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) have been widely used as a model for human stomach cancers of the differentiated type. However, there has been little information regarding their molecular basis. In this study, we examined the genetic alterations reported in