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Infrequent Ki-ras and an absence of p53 mutations in hepatocellular carcinomas induced by a choline deficient l-amino acid defined diet in rats

✍ Scribed by Toshifumi Tsujiuchi; Akira Kido; Dai Nakae; Makoto Takahama; Toshimitsu Majima; Kunihiko Kobitsu; Eijiro Okajima; Masahiro Tsutsumi; Ayumi Denda; Yoichi Konishi


Book ID
117468336
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
482 KB
Volume
108
Category
Article
ISSN
0304-3835

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CpG site hypermethylation of E-cadherin
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## Abstract We investigated DNA methylation patterns of E‐cadherin and Connexin26 (Cx26) genes in rat hepatocellular carcinomas (HCCs) induced by a choline‐deficient L‐Amino Acid‐defined (CDAA) diet. Six‐wks‐old F344 male rats were continuously fed with a CDAA diet for 75 wks, and were then killed.

Alterations of the M6p/Igf2 receptor gen
✍ Toshifumi Tsujiuchi; Yasutaka Sasaki; Yasuo Oka; Hiroki Kuniyasu; Yoichi Konishi 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 197 KB

## Abstract To elucidate whether the M6p/Igf2 receptor (M6p/Igf2r) gene might be involved in exogenous and endogenous liver carcinogenesis, we investigated its alteration in hepatocellular carcinomas (HCCs) induced by __N__‐nitrosodiethylamine (DEN) and by a choline‐deficient L‐amino acid‐defined (