Hypomethylation of CpG Sites andc-mycGene Overexpression in Hepatocellular Carcinomas, but Not Hyperplastic Nodules, Induced by a Choline-deficient L-Amino Acid-defined Diet in Rats
✍ Scribed by Tsujiuchi, Toshifumi ;Tsutsumi, Masahiro ;Sasaki, Yasutaka ;Takahama, Makoto ;Konishi, Yoichi
- Book ID
- 108581804
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 1999
- Tongue
- English
- Weight
- 227 KB
- Volume
- 90
- Category
- Article
- ISSN
- 0910-5050
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## Abstract We investigated DNA methylation patterns of E‐cadherin and Connexin26 (Cx26) genes in rat hepatocellular carcinomas (HCCs) induced by a choline‐deficient L‐Amino Acid‐defined (CDAA) diet. Six‐wks‐old F344 male rats were continuously fed with a CDAA diet for 75 wks, and were then killed.
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