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p53-mediated transcription induces resistance of DNA to UV inactivation

โœ Scribed by Huang, Jinghua; Logsdon, Naomi; Schmieg, Florence I; Simmons, Daniel T


Book ID
110061440
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
393 KB
Volume
17
Category
Article
ISSN
0950-9232

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## Abstract Compared to proliferating keratinocytes (KCs), growthโ€arrested KCs are relatively resistant to UVโ€light induced apoptosis. When KCs undergo confluency, or following exposure to antiโ€proliferative agents such as IFNโ€ฮณ plus a phorbol esterโ€“12โ€__O__โ€tetradecanoylyphorbolโ€13โ€acetate (TPA),