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UV-C-induced DNA damage leads to p53-dependent nuclear trafficking of PML

โœ Scribed by Seker, Hasan; Rubbi, Carlos; Linke, Steven P; Bowman, Elise D; Garfield, Susan; Hansen, Laura; Borden, Katherine LB; Milner, Jo; Harris, Curtis C


Book ID
110067262
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
527 KB
Volume
22
Category
Article
ISSN
0950-9232

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## Abstract It is generally accepted that exposure of cells to a variety of DNAโ€damaging agents leads to upโ€regulation and activation of wildโ€type (wt) p53 protein. We investigated the (re)โ€activation of p53 protein in two human cancer cell lines in which the gene for this tumor suppressor is not m