The effect of expression of the p53 gene, in the presence or absence of the p53ser246 mutation (p53\*), on ploidization (image cytometry), proliferation (expression of proliferating cell nuclear antigen and radioactive thymidine histoautoradiography), and apoptosis (in situ detection of DNA fragment
p53 may positively regulate hepatocyte proliferation in rats
โ Scribed by Yukiko Inoue; Tomoaki Tomiya; Mikio Yanase; Masahiro Arai; Hitoshi Ikeda; Kazuaki Tejima; Itsuro Ogata; Satoshi Kimura; Masao Omata; Kenji Fujiwara
- Book ID
- 111721944
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 370 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0270-9139
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
We read with interest the article by Van Gijssel et al. published recently in HEPATOLOGY, 1 where, employing a Solt-Faber protocol, these investigators show an attenuated nuclear accumulation of p53 in response to DNA damage in preneoplastic lesions in vivo. We would like to point out that there are
## Abstract Livers from wildโtype and p53โdeficient mice were analyzed for the expression of cellโcycle regulatory proteins in an attempt to determine the mechanism for the increased proliferation of liver cells in p53โdeficient mice associated with enhanced susceptibility to aflatoxinโinduced live