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p53 in the Clinics || Mutant p53-Driven Tumorigenesis

✍ Scribed by Hainaut, Pierre; Olivier, Magali; Wiman, Klas G.


Book ID
118015542
Publisher
Springer New York
Year
2012
Weight
371 KB
Category
Article
ISBN
1461436761

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Tumorigenesis in p27/p53- and p18/p53-do
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Mice lacking both p18 Ink4c and p27 Kip1 develop a tumor spectrum similar to pRb ΓΎ/Γ€ mice, and loss of p53 function accelerates tumorigenesis in pRb ΓΎ/Γ€ mice. We hypothesized that codeletion of either p18 or p27 in conjunction with p53 deletion will also accelerate tumorigenesis. Mice lacking both p