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P53 gene mutations and steroid receptor status in breast cancer. Clinicopathologic correlations and prognostic assessment

✍ Scribed by Maira Caleffi; Mark W. Teague; Roy A. Jensen; Cindy L. Vnencak-Jones; William D. Dupont; Fritz F. Parl

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 880 KB
Volume: 73
Category: Article
ISSN: 0008-543X
DOI: 10.1002/1097-0142(19940415)73:8<2147::aid-cncr2820730820>3.0.co;2-5

No coin nor oath required. For personal study only.

✦ Synopsis

Background. There is increasing evidence linking development and progression of cancer to an accumulation of mutations at the genomic level. The most frequently mutated gene known to date in sporadic breast cancer appears to be the tumor suppressor gene p53. This study was designed to determine the frequency of p53 gene mutations in primary breast cancer, to correlate the presence of p53 mutations with established clinicopathologic parameters, including the estrogen receptor (ER) and progesterone receptor (PR) status, and to assess the prognostic significance of p53 mutations regarding patient survival.

Methods. We examined the p53 gene in genomic DNA samples from 192 primary breast cancers. Using denaturant gradient gel electrophoresis, the authors analyzed exons 5-9 in all tumors for mutations and performed DNA sequencing in 20 tumors to identify the exact nature of the p53 mutations.

Results. p53 gene alterations were identified in 43 of the 192 tumors (22%), the majority localized in exons 5 and 6. DNA sequencing showed mostly missense mutations resulting from G or C substitutions. p53 mutations were found more often in tumors of younger women ( P = 0.002), Afro-American women ( P = 0.05), and in tumors lacking ER (P = 0.03), PR (P = 0.04), or both (P = 0.06).

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