p53 Gene Mutation in Hepatocellular Carcinoma Induced by 2-Amino-3-methylimidazo[4,5-f]quinoline in Nonhuman Primates
✍ Scribed by Fujimoto, Yoshinori ;Hampton, Lori L. ;Snyderwine, Elizabeth G. ;Nagao, Minako ;Sugimura, Takashi ;Adamson, Richard H. ;Thorgeirsson, Snorri S.
- Book ID
- 108580834
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 1994
- Tongue
- English
- Weight
- 230 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0910-5050
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## Abstract 2‐Amino‐3‐methylimidazo[4,5‐__f__]quinoline (IQ) is a very potent mutagen that is carcinogenic in rodents and nonhuman primates. IQ‐induced CDF~1~ mouse lung and liver tumors were examined for activated Ki‐__ras__ and Ha‐__ras__ genes, respectively. Polymerase chain reaction (PCR)—ampli
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