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p53 family members in myogenic differentiation and rhabdomyosarcoma development

✍ Scribed by Hakan Cam; Heidi Griesmann; Michaela Beitzinger; Lars Hofmann; Rasa Beinoraviciute-Kellner; Markus Sauer; Nicole Hüttinger-Kirchhof; Claudia Oswald; Peter Friedl; Stefan Gattenlöhner; Christof Burek; Andreas Rosenwald; Thorsten Stiewe


Book ID
113523713
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
989 KB
Volume
10
Category
Article
ISSN
1535-6108

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Role of p53 family members in apoptosis
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p53-mediated apoptosis involves multiple mechanisms. A number of p53-regulated apoptosis-related genes have been identified. Some of these genes encode proteins that are important in controlling the integrity of mitochondria while the others code for membrane death receptors. p53 may also induce apo