p53 family members in cancer diagnosis and treatment
✍ Scribed by Alice Machado-Silva; Stéphane Perrier; Jean-Christophe Bourdon
- Book ID
- 113900441
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 514 KB
- Volume
- 20
- Category
- Article
- ISSN
- 1044-579X
No coin nor oath required. For personal study only.
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Based on gene sequence homologies, a p53 (TP53) gene family become apparent with the addition of the most recently identified p63 (TP73L; formerly TP63) and p73 (TP73) genes to the already known p53. The p53 gene encodes for a unique protein eliciting well-known tumor suppressor gene (TSG) propertie
p53-mediated apoptosis involves multiple mechanisms. A number of p53-regulated apoptosis-related genes have been identified. Some of these genes encode proteins that are important in controlling the integrity of mitochondria while the others code for membrane death receptors. p53 may also induce apo