p53-dependent regulation of heat shock protein 72
β Scribed by L.A. Quenneville; M.J. Trotter; T. Maeda; V.A. Tron
- Book ID
- 104460122
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 769 KB
- Volume
- 146
- Category
- Article
- ISSN
- 0007-0963
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Heat shock proteins (hsp) are molecular chaperones that are increased by various environmental and patho-physiological stimuli. Hsp can bind to mutant/wild-type p53 in tumors and, consequently, could not only regulate p53 accumulation or localization but also modulate its biological effects on cells
M-14 human melanoma cells, following severe hyperthermic exposures, synthesized a heat-shock protein of 66 kDa (hsp 66), in addition to the major "classic" heat-shock proteins. This hsp 66 was not expressed following mild hyperthermic exposures sufficient to trigger the synthesis of the other heat-s