The induction of WAF1 gene expression after the treatment with the anticancer agent 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU; nimustine hydrochloride) was studied in two human glioblastoma cell lines: U-87MG, which bears the wild-type p53 gene, and
โฆ LIBER โฆ
p53-dependent induction of WAF1 by cold shock in human glioblastoma cells
โ Scribed by Ohnishi, Takeo; Wang, Xinjiang; Ohnishi, Ken; Takahashi, Akihisa
- Book ID
- 110061207
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 818 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0950-9232
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The p53 protein directly regulates the expression of the WAFl (wild-type p53activated fragment 1) protein which is a cyclin-dependent kinase inhibitor (CDKI). DNA damaging agents such as ionizing or UV radiation, and some chemical agents induce WAF1 in wild-type p53 containing cells, thereby halting