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p53-dependent apoptosis and transcription of p21waf/cip1/sdi1 in SCID mice following γ-irradiation

✍ Scribed by S.M. Candéias; S.K. Durum; K. Muegge


Book ID
117457076
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
496 KB
Volume
79
Category
Article
ISSN
0300-9084

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Codon 273 is one of the hot spots of missense mutation of the p53 tumor suppressor gene found in human cancers. We have previously reported that a mutation at codon 273, p53-273L (Arg 3 Leu), suppresses cell growth despite its having no p53-specific transactivation activity. To further elucidate the