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p53 de-ubiquitination: at the edge between life and death

✍ Scribed by Salomoni, Paolo; Pandolfi, Pier Paolo


Book ID
109911659
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
155 KB
Volume
4
Category
Article
ISSN
1465-7392

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## Abstract Overexpression of Cyclooxygenase‐2 (COX‐2) is observed in most tumor types. Increased COX‐2 activity and synthesis of prostaglandins stimulates proliferation, angiogenesis, invasiveness and inhibits apoptosis. Many stress and proinflammatory signals induce COX‐2 expression, including ox