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p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug

✍ Scribed by Wang, Shu-Ping; Wang, Wen-Lung; Chang, Yih-Leong; Wu, Chen-Tu; Chao, Yu-Chih; Kao, Shih-Han; Yuan, Ang; Lin, Chung-Wu; Yang, Shuenn-Chen; Chan, Wing-Kai


Book ID
109911811
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
302 KB
Volume
11
Category
Article
ISSN
1465-7392

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TGF-β–induced invasiveness of pancreatic
✍ Volker Ellenrieder; Sandra F. Hendler; Claudia Ruhland; Wolfgang Boeck; Guido Ad πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 French βš– 216 KB

TGF-beta strongly promotes local tumor progression in advanced epithelial tumors, though the underlying mechanisms are poorly understood. In the present study, we demonstrate the potential of TGF-beta to increase the invasiveness of the pancreatic cancer cell lines PANC-1 and IMIM-PC1. TGF-beta-indu