## Abstract The polymorphisms of the tumor suppressor gene p53 have been extensively investigated in numerous malignant tumors, particularly carcinomas associated with human papillomavirus (HPV) infection. However, the results remain controversial. To address a potential correlation between the p53
p53 codon 72 polymorphism in basal cell carcinoma of the skin
β Scribed by Abdulmohammad Pezeshki; Fatemeh Sari-Aslanl; Abbas Ghaderi; Mehrnoosh Doroudchi
- Publisher
- Springer Netherlands
- Year
- 2006
- Tongue
- English
- Weight
- 93 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1219-4956
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The association between human papillomavirus (HPV)-associated cervical cancer and cutaneous squamous cell carcinoma and codon 72 polymorphism in the p53 gene is not unequivocal. Especially, it is not known whether carriers of the arginine form have an increased risk of cancer that necessitates scree
## Abstract The p53 gene is involved in the control of cellβcycle arrest and apoptosis. The germline Arg72Pro polymorphism alters the protein's biochemical functions, and may confer individual susceptibility to skin cancer. We evaluated the association of the Arg72Pro polymorphism with skin cancer
## Abstract ## BACKGROUND. Tobacco smoking, alcohol abuse, and highβrisk human papillomavirus (HPV) are risk factors in the etiology of oropharyngeal squamous cell carcinomas (SCCs). The __TP53__ polymorphism, in which an arginine (R) is changed to proline (P) at codon 72, is functionally signific
## Background: Human papillomavirus (hpv) plays an important role in the development of carcinomas at various body sites. it was found previously that the p53 codon 72 polymorphism (c/g) is a high-risk factor for the development hpv-associated cervical carcinoma. however, it still was considered co