✦ LIBER ✦

p53 Codon 72 polymorphism and the risk of esophageal squamous cell carcinoma

✍ Scribed by Wenjun Yang; Yanyan Zhang; Xiuyun Tian; Tao Ning; Yang Ke

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 90 KB
Volume: 47
Category: Article
ISSN: 0899-1987
DOI: 10.1002/mc.20368

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The polymorphisms of the tumor suppressor gene p53 have been extensively investigated in numerous malignant tumors, particularly carcinomas associated with human papillomavirus (HPV) infection. However, the results remain controversial. To address a potential correlation between the p53 genotypes and the risk of esophageal squamous cell carcinoma (ESCC), we investigated the p53 codon 72 polymorphism in 435 patients with ESCC and 550 cancer‐free subjects from the same geographical region. p53 Arg/Arg genotype was significantly increased in ESCC cases compared with control subjects (85.7 vs. 49.6%, P < 0.001), resulting in an elevated ESCC risk (OR = 6.48, 95% CI = 4.65–9.03). In addition, among p53 Arg/Arg carriers, HPV infection, smoking, and drinking might further increase the risk of ESCC development. © 2007 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Cutaneous squamous cell carcinoma and p5

Cutaneous squamous cell carcinoma and p53 codon 72 polymorphism: A need for screening?

✍ Maarten T. Bastiaens; Linda Struyk; Steven P. Tjong-A-Hung; Nelleke Gruis; Jeann 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 105 KB

The association between human papillomavirus (HPV)-associated cervical cancer and cutaneous squamous cell carcinoma and codon 72 polymorphism in the p53 gene is not unequivocal. Especially, it is not known whether carriers of the arginine form have an increased risk of cancer that necessitates scree

p53 codon 72 polymorphisms in human papi

p53 codon 72 polymorphisms in human papillomavirus-negative and human papillomavirus-positive squamous cell carcinomas of the oropharynx

✍ Federica Perrone; Luigi Mariani; Elisa Pastore; Marta Orsenigo; Simona Suardi; B 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 81 KB

## Abstract ## BACKGROUND. Tobacco smoking, alcohol abuse, and high‐risk human papillomavirus (HPV) are risk factors in the etiology of oropharyngeal squamous cell carcinomas (SCCs). The __TP53__ polymorphism, in which an arginine (R) is changed to proline (P) at codon 72, is functionally signific

Effects of MDM2 promoter polymorphisms a

Effects of MDM2 promoter polymorphisms and p53 codon 72 polymorphism on risk and age at onset of squamous cell carcinoma of the head and neck

✍ Hongping Yu; Yu-jing Huang; Zhensheng Liu; Li-E Wang; Guojun Li; Erich M. Sturgi 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 422 KB 👁 1 views

## Abstract Both p53 tumor suppressor and murine double minute 2 (MDM2) oncoprotein are crucial in carcinogenesis. We hypothesized that __MDM2__ promoter single nucleotide polymorphisms (SNPs) SNP309 T > G, A2164G, and __p53__ codon 72 are associated with risk and age at onset of squamous cell carc

Association of p53 codon 72 polymorphism

Association of p53 codon 72 polymorphism with risk of second primary malignancy in patients with squamous cell carcinoma of the head and neck

✍ Fanglin Li; Erich M. Sturgis; Xingming Chen; Mark E. Zafereo; Qingyi Wei; Guojun 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 185 KB 👁 2 views

p53 codon 72 polymorphism (C/G) and the

p53 codon 72 polymorphism (C/G) and the risk of human papillomavirus-associated carcinomas in China

✍ Tao Li; Zhe-Ming Lu; Mei Guo; Qin-Jiao Wu; Ke-Neng Chen; Hai-Ping Xing; Qiang Me 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 143 KB 👁 1 views

## Background: Human papillomavirus (hpv) plays an important role in the development of carcinomas at various body sites. it was found previously that the p53 codon 72 polymorphism (c/g) is a high-risk factor for the development hpv-associated cervical carcinoma. however, it still was considered co

The p53 codon 72 polymorphism, sunburns,

The p53 codon 72 polymorphism, sunburns, and risk of skin cancer in US caucasian women

✍ Jiali Han; David G. Cox; Graham A. Colditz; David J. Hunter 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 194 KB 👁 1 views

## Abstract The p53 gene is involved in the control of cell‐cycle arrest and apoptosis. The germline Arg72Pro polymorphism alters the protein's biochemical functions, and may confer individual susceptibility to skin cancer. We evaluated the association of the Arg72Pro polymorphism with skin cancer