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p53 and little brother p53/47: linking IRES activities with protein functions

✍ Scribed by Grover, R; Candeias, M M; Fåhraeus, R; Das, S


Book ID
109970938
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
296 KB
Volume
28
Category
Article
ISSN
0950-9232

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## Abstract We report that MDM2, a negative regulator of p53, can bind to EBNA‐5. Using GST pull‐down assay, immunoprecipitation, surface plasmon resonance and immunostaining of lymphoblastoid cells, we found that trimolecular complexes are formed between EBNA‐5, MDM2 and p53, where MDM2 serves as