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P53 and Fas/APO-1 induction in hepatoma cells in response to treatment with DNA damaging agents

✍ Scribed by MUELLER, M

Book ID
123521265
Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
148 KB
Volume
22
Category
Article
ISSN
0270-9139

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p53 mutations are found in about 70% of human cancers. In order to evaluate the role of these mutations in response to chemotherapeutic agents, it is important to distinguish between p53 response to DNA-damaging agents in normal and in tumour cells. Here, using normal human fibroblasts (NHFs), we sh