p27(Kip1), an important regulator of Cdk2 activity and G 1 /S transition, is tightly regulated in a cell-type and condition-specific manner to integrate mitogenic and differentiation signals governing cell cycle progression. We show that p27 protein levels progressively declined from mid-G 1 through
✦ LIBER ✦
p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells
✍ Scribed by Sutterlüty, Hedwig; Chatelain, Eric; Marti, Alain; Wirbelauer, Christiane; Senften, Matthias; Müller, Uli; Krek, Wilhelm
- Book ID
- 109487268
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 693 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1465-7392
- DOI
- 10.1038/12027
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