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Bortezomib-mediated expression of p27Kip1 through S-phase kinase protein 2 degradation in epithelial ovarian cancer

โœ Scribed by Uddin, Shahab; Ahmed, Maqbool; Hussain, Azhar R; Jehan, Zeenath; Al-Dayel, Fouad; Munkarah, Adnan; Bavi, Prashant; Al-Kuraya, Khawla S


Book ID
109885388
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
541 KB
Volume
89
Category
Article
ISSN
0023-6837

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## Abstract ## BACKGROUND Low levels of p27^Kip1^ are associated with high aggressiveness and poor prognosis in various malignancies, including colorectal carcinoma. The authors showed that S phase kinase protein 2 (Skp2), the specific ubiquitin ligase subunit that targets p27^Kip1^ for degradatio