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P4-384 Minocycline blocks C-terminal fragments of amyloid precursor protein-induced neurotoxicity by inhibition cytochrome C release and caspase-12 activation

✍ Scribed by Choi, Yoori; Kim, Eun-Mee; Suh, Yoo-Hun

Book ID: 122469548
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 164 KB
Volume: 25
Category: Article
ISSN: 0197-4580
DOI: 10.1016/S0197-4580(04)81942-0

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## Abstract The AICD (APP intracellular Domain) and C31, caspase‐cleaved C‐terminal fragment of APP, have been found in Alzheimer's disease (AD) patients' brains and have been reported to induce apoptosis in neuronal cells. In recent, the C‐terminal fragments of amyloid precursor protein (APP‐CTs)