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P4-306 Functional analysis of nicastrin and PEN-2 in γ-secretase complex

✍ Scribed by Noriko, Isoo; Makiko, Tsuruoka; Makoto, Miyagishi; Kazunari, Taira; Shoji, Tsuji; Taisuke, Tomita; Takeshi, Iwatsubo

Book ID
123175619
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
154 KB
Volume
25
Category
Article
ISSN
0197-4580

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## Abstract The γ‐secretase complex has emerged as an unusual membrane‐bound aspartyl protease with the ability to cleave certain substrate proteins at peptide bonds believed to be buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key biochemical ste