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P4-293 The presenilins, chromosome missegregation, and Alzheimer's disease

โœ Scribed by Boeras, Debrah I.; Granic, Antoneta; Padmanabhan, Jaya; Potter, Huntington


Book ID
122966670
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
161 KB
Volume
25
Category
Article
ISSN
0197-4580

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Mutations in the presenilin genes (PS-1 and PS-2) cause early onset autosomal dominant Alzheimer's disease (AD). Eight early-onset, autopsy-documented familial AD kindreds were screened for mutations in PS-1, and seven different mutations were identified. Three of these were new mutations (G209V, A4