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P4-253 Oxidative stress and antioxidant defenses in mild cognitive impairment and Alzheimer's disease

✍ Scribed by Oliveira, Catarina; Baldeiras, Inês; Proença, Teresa; Garrucho, Helena; Pascoal, Rui; Santiago, Beatriz; Santana, Isabel

Book ID: 123367560
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 167 KB
Volume: 25
Category: Article
ISSN: 0197-4580
DOI: 10.1016/S0197-4580(04)81811-6

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## Abstract Increasing evidence supports a role for oxidative damage in the pathogenesis of Alzheimer's disease (AD). Multiple studies show significantly increased levels of lipid peroxidation and protein, DNA, and RNA oxidation in vulnerable regions of the brain of patients with late‐stage AD (LAD