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Oxidative stress and APO E polymorphisms in Alzheimer's disease and in mild cognitive impairment

✍ Scribed by Chico, L.; Simoncini, C.; Lo Gerfo, A.; Rocchi, A.; Petrozzi, L.; Carlesi, C.; Volpi, L.; Tognoni, G.; Siciliano, G.; Bonuccelli, U.

Book ID
121421278
Publisher
Informa plc
Year
2013
Tongue
English
Weight
326 KB
Volume
47
Category
Article
ISSN
1071-5762

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## Abstract Increasing evidence supports a role for oxidative damage in the pathogenesis of Alzheimer's disease (AD). Multiple studies show significantly increased levels of lipid peroxidation and protein, DNA, and RNA oxidation in vulnerable regions of the brain of patients with late‐stage AD (LAD