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P4-072 Follow-up analysis of chromosome 2 linkage in early-onset Alzheimer disease

✍ Scribed by Browning, Carrie; Vance, Danica D.; Bronson, Paola G.; Schmechel, Donald; Welsh-Bohmer, Kathleen; Scott, William; Haines, Jonathan L.; Vance, Jeffery M.; Pericak-Vance, Margaret A.


Book ID
122732075
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
163 KB
Volume
25
Category
Article
ISSN
0197-4580

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Linkage of familial alzheimer disease to
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Alzheimer disease (AD) is a devastating neurodegenerative disease leading to global dementia. In addition to sporadic forms of AD, familial forms (FAD) have been recognized. Mutations in the amyloid precursor protein (APP) gene on chromosome (CHR) 21 have been shown to cause early-onset AD in a smal