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p38 MAPK signaling pathway is involved in transforming growth factor-β (TGF-β)/Smad3-induced apoptosis

✍ Scribed by Li, Fazhi; Cao, Yanna; Townsend, Courtney M.; Ko, Tien C.


Book ID
123524878
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
361 KB
Volume
124
Category
Article
ISSN
0016-5085

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## Abstract Previously, we demonstrated the pivotal role of the vitamin D receptor (VDR) in mediating the butyrate‐induced differentiation in colon cancer cells. Smad 3, a downstream component of transforming growth factor‐β (TGFβ) signaling, has been shown to act as a coactivator of VDR and to pos