P36 CIP-1 protein expression in node-positive breast cancer patients
β Scribed by P. Hupperets; E. Thunnissen; J. Peterse; H. Schouten
- Book ID
- 117665473
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 305 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0959-8049
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## Abstract The cyclinβdependent kinase inhibitor protein p21^Waf1/Cip1^ is a potent tumor suppressor. Here, we demonstrate that estradiol regulates the p21^Waf1/Cip1^ gene. Estradiol induces p21^Waf1/Cip1^ mRNA expression within 30β60βmin independent of new protein synthesis in the estrogen recept
BACKGROUND. p21(waf1/cip1) protein is a cyclin-dependent kinase inhibitor able to arrest the cell cycle at the G1 phase by inhibiting DNA replication. The expression of p21(waf1/cip1) and its prognostic value in prostate cancer are largely unexplored. METHODS. We used immunohistochemistry to analyze