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P319 Prostaglandin E2 receptors EP1 and EP4 are upregulated in rabbit chondrocytes by IL-1β but not by TNFα

Book ID
114349261
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
227 KB
Volume
13
Category
Article
ISSN
1063-4584

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✍ Kazunari Fushimi; Shigeru Nakashima; Fukka You; Masaharu Takigawa; Katsuji Shimi 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 250 KB

## Abstract Matrix metalloproteinase‐1 (MMP‐1, collagenase‐1) plays a pivotal role in the process of joint destruction in degenerative joint diseases. We have examined the regulation of MMP‐1 production in human chondrocytic HCS‐2/8 cells stimulated by tumor necrosis factor‐α (TNF‐α). In response t