## Abstract Matrix metalloproteinase‐1 (MMP‐1, collagenase‐1) plays a pivotal role in the process of joint destruction in degenerative joint diseases. We have examined the regulation of MMP‐1 production in human chondrocytic HCS‐2/8 cells stimulated by tumor necrosis factor‐α (TNF‐α). In response t
✦ LIBER ✦
Prostaglandin E2 receptors EP1 and EP4 are up-regulated in rabbit chondrocytes by IL-1β, but not by TNFα
✍ Scribed by M. Angeles Alvarez-Soria; Raquel Largo; Olga Sanchez-Pernaute; Emilio Calvo; Jesús Egido; Gabriel Herrero-Beaumont
- Book ID
- 106007310
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 424 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0172-8172
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## Abstract ## Objective We reported previously that the orphan nuclear receptor, estrogen receptor–related receptor α (ERRα), is expressed in articular chondrocytes and is dysregulated in a mouse model of inflammatory arthritis. The aim of this study, therefore, was to determine whether ERRα is a