P3.153 PLA2G6 mutations in a Taiwanese cohort of early onset parkinsonism
✍ Scribed by Y.-H. Wu-Chou; C.-S. Lu; H.-C. Chang; R.-S. Chen; Y.-H. Weng; S.-C. Lai; T.-H. Yeh
- Book ID
- 117753920
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 67 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1353-8020
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Recently, mutations in __DJ‐1__ (PARK7) were described as a novel cause of early‐onset parkinsonism. We analysed the __DJ‐1__ gene in a cohort of patients originating from Taiwan with early‐onset Parkinson's disease; 41 subjects were clinically and genetically examined. These patients w
## Abstract Recent reports suggest that CAG triplet expansions of spinocerebellar ataxia type 2 and 3 (__SCA2__ and __SCA3__) genes are the cause of typical levodopa‐responsive Parkinson's disease (PD) in familial cases, several of which were ethnic Chinese. To investigate the role of __SCA2__ and
## Abstract Seven autosomal recessive genes associated with juvenile and young‐onset Levodopa‐responsive parkinsonism have been identified. Mutations in __PRKN__, __DJ‐1__, and __PINK1__ are associated with a rather pure parkinsonian phenotype, and have a more benign course with sustained treatment
## Abstract Mutations in the leucine‐rich repeat kinase 2 (__LRRK2__) gene have been shown to cause autosomal dominant and sporadic Parkinson's disease (PD). We report here the frequency of a common heterozygous mutation, 2877510G>A, which produces a glycine‐to‐serine amino acid substitution at cod