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P303 Rhein, the metabolite of diacerhein, modulates cell signaling and gene expression of articular chondrocytes cultured in hypoxia


Book ID
114349245
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
112 KB
Volume
13
Category
Article
ISSN
1063-4584

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## Abstract ## Objective To determine the effects of hypoxia and reoxygenation on the metabolism of chondrocytes and their response to interleukin‐1Ξ² (IL‐1Ξ²). The study included activation of hypoxia‐inducible factor 1 (HIF‐1), NF‐κB, and activator protein 1 (AP‐1) transcription factors, expressio