Glutamate signaling in chondrocytes and the potential involvement of NMDA receptors in cell proliferation and inflammatory gene expression
β Scribed by T. Piepoli; L. Mennuni; S. Zerbi; M. Lanza; L.C. Rovati; G. Caselli
- Book ID
- 113732957
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 627 KB
- Volume
- 17
- Category
- Article
- ISSN
- 1063-4584
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We evaluated expression of N-methyl-D-aspartate (NMDA) and non-NMDA glutamate receptor (GluR) genes by reverse transcriptase-polymerase chain reaction (RT-PCR) and Southern blotting in nine established cell lines: rat CG-4 (oligodendroglial lineage) and RINm5F insulinoma cells; human CHP134, SMS-KCN
## Abstract We previously identified functional __N__βmethylβdβaspartate (NMDA) glutamate receptors in mature osteoclasts and demonstrated that they are involved in bone resorption in vitro. In the present work, we studied the expression of NMDA receptors (NMDAR) by osteoclast precursors and their